THE SCIENCE BEHIND TANO

A Clinically Validated Breakthrough in Skin Support.

Building stronger skin without unnecessary irritation.

After extensive lab research and third-party testing, banana sap is shown to support collagen signaling and skin resilience.

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A Clinically Validated Breakthrough in Skin Support.

CLINICAL RESULTS: BANANA SAP

Independent testing shows measurable improvements in collagen support, barrier integrity, hydration, and visible skin firmness.

All data based on controlled in-vitro and pathway activation testing.

Measured 324% Increase in Collagen Production

Banana sap activates key collagen-support pathways associated with structural skin integrity. In controlled third-party testing, it demonstrated a 324% increase in collagen production compared to baseline; exceeding commonly used cosmetic actives, including retinoids (~80%).

The result: visibly firmer, more resilient-looking skin without barrier disruption.

BANANA SAP*

PEPTIDES

RETINOIDS

VITAMIN C

NIACINAMIDE

GLYCOLIC ACID

324

100

80

50

35

25

50 100 150 200 250 300 350

INCREASE OVER BASELINE COLLAGEN PRODUCTION (%)

*independent third-party testing conducted November 2024 measuring Banana sap collagen stimulation in a collagen synthesis assay (ELISA protocol).

Visibly Softer Fine Lines Backed by Real Biology

In advanced testing using a full-thickness human skin model, banana sap increased the activity of collagen genes like COL1A1 (+59%), which play a central role in keeping skin firm and smooth. Independent laboratory studies also showed up to 4.2x increases in Type I collagen production (the primary collagen responsible for wrinkle resistance) along with a 51% reduction in collagen-degrading enzymes. The result is support for smoother-looking skin through two pathways: helping your skin make more collagen while protecting the collagen you already have.

In clinical evaluation of Age Well Face Cream, participants reported visible improvements in fine lines, firmness, and overall skin texture with consistent use.

Before

After

Stronger Barrier Support Measured at the Skin-Cell Level

When the skin barrier is strong, skin holds moisture better, looks smoother, and feels calmer. When it’s compromised, irritation and dryness are easier to trigger.

In advanced testing using a full-thickness human skin model, banana sap + hyaluronic acid triggered gene-level signals associated with barrier integrity and recovery. This includes strengthening the “connections” between skin cells (tight junctions), supporting repair signaling, and reducing inflammatory triggers that can destabilize the barrier.

The result is barrier support through multiple pathways: helping skin repair, seal, and stay calm over time.

TJP2

↑

2.32X

TIGHT JUNCTION SUPPORT

Helps strengthen the links between skin cells (key for barrier integrity).

HGF

↑

2.53X

REPAIR SIGNALING

Supports recovery and regeneration response.

FGF2

↑

2.26X

STRUCTURAL RECOVERY SUPPORT

Associated with repair and tissue resilience.

ADAM17

↓

1.48X

REDUCED INFLAMMATORY ACTIVATION

A signal associated with dialing down inflammatory triggers that can weaken the barrier.

Designed for Skin Prone to Eczema, Rosacea, and Sensitivity

Conditions like eczema, rosacea, psoriasis, and chronic sensitivity are often associated with elevated inflammatory signaling in the skin.

In advanced gene expression testing using a full-thickness human skin model, banana sap demonstrated significant downregulation of inflammatory mediators associated with epithelial stress and immune overactivation.

Notably, IL17C — a cytokine involved in inflammatory amplification pathways commonly elevated in redness-prone and psoriasis-associated skin — was significantly reduced.

Additional reductions were observed in CCL24 and CXCR6, signaling molecules associated with immune cell recruitment and inflammatory persistence.

Rather than triggering irritation-based renewal, banana sap supports calmer skin biology at the signaling level — making it especially suitable for individuals who struggle with reactive, redness-prone, or barrier-compromised skin.

+33% Hydration in 30 Minutes. +50% Sustained. +16% Improved Elasticity.

In controlled clinical evaluation of Age Well Face Cream, skin hydration increased by 33% within 30 minutes, with a 50% sustained increase at 4 weeks, measured via corneometer-based skin capacitance analysis.

Skin elasticity improved by 16%, measured using cutometer mechanical recoil testing.

Beyond the finished formula, gene expression testing of the banana sap + hyaluronic acid system in a full-thickness human skin model demonstrated increased tight junction support (TJP2 ↑ 2.32x), alongside regenerative signaling associated with structural resilience (HGF ↑ 2.53x, FGF2 ↑ 2.26x).

Together, these signals align with improved moisture retention and mechanical skin resilience over time.

TJP2

↑

2.32X

TIGHT JUNCTION reinforcement

Helps strengthen the links between skin cells (key for barrier integrity).

HGF

↑

2.53X

REPAIR SIGNALING

Supports recovery and regeneration response.

FGF2

↑

2.26X

STRUCTURAL RECOVERY SUPPORT

Associated with repair and tissue resilience.

THE PROOF IS IN THE SCIENCE

Measured results from controlled product testing and participant feedback.

COLLAGEN SUPPORT & VISIBLE FIRMNESS

AGE WELL FACE CREAM

Clinically Measured Skin Renewal

Clinical Findings:

91%

of participants saw visibly smoother skin

15.6%

reported improved elasticity

33%

immediate hydration boost

LEARN MORE

RETINOID-FREE

PREGNANCY SAFE

HRIPT TESTED

MEETS EU CLEANLINESS STANDARDS

THE SCIENCE OF SKIN AGING

SCIENCE OF COLLAGEN DECLINE.

Collagen is the structural protein that maintains skin firmness, elasticity, and resilience. Beginning in early adulthood, collagen synthesis gradually declines as cellular signaling slows and fibroblast activity decreases. This process affects both women and men, though research shows women can experience a sharper acceleration in collagen loss during hormonal transitions such as menopause.

While many cosmetic ingredients claim to boost collagen, measurable increases in collagen production are rarely quantified. The charts below illustrate age-related collagen decline and compare third-party assay data measuring banana sap against commonly used cosmetic actives.

Male
Female

RELATIVE COLLAGEN LEVELS (%)

100 80 60 40 20

20 30 40 50 60 70

AGE Based on metadata analysis of publicly available papers on collagen decline in skin

BANANA SAP*

PEPTIDES

RETINOIDS

VITAMIN C

NIACINAMIDE

GLYCOLIC ACID

324

100

80

50

35

25

INCREASE OVER BASELINE COLLAGEN PRODUCTION (%)

*Banana sap collagen stimulation results based on independent third-party testing conducted November 2024 using a collagen synthesis assay (ELISA protocol).

AGE Based on metadata analysis of publicly available papers on collagen decline in skin

INCREASE OVER BASELINE COLLAGEN PRODUCTION (%)

*Banana sap collagen stimulation results based on independent third-party testing conducted November 2024 using a collagen synthesis assay (ELISA protocol).

Shuster, S., Black, M. M., & McVitie, E. (1975). The influence of age and sex on skin thickness, skin collagen and density. View study

Brincat, M., et al. (1987). A study of the decrease of skin collagen content, skin thickness, and bone mass in the postmenopausal woman. View study